abstract：:Cerebellar torpedoes, unique fusiform swellings of Purkinje cell axons within the granular layer, have been known to occur sparsely associated with diffuse cerebellar changes. This report describes, in three human autopsy cases with focal necrotic lesions in the cerebellar white matter, torpedoes which were essentiall...

journal_title：Acta neuropathologica

authors： Takahashi N,Iwatsubo T,Nakano I,Machinami R

更新日期：1992-01-01 00:00:00

abstract：:The growth potential of 65 pituitary adenomas was determined by histochemical analysis with Ki-67 and anti-DNA polymerase alpha monoclonal antibodies, bromodeoxyuridine (BrdUdR) labeling, and counts of argyrophilic nucleolar organizer regions (Ag-NORs). The mean proliferating cell indices (PCIs) determined by Ki-67 an...

journal_title：Acta neuropathologica

authors： Shibuya M,Saito F,Miwa T,Davis RL,Wilson CB,Hoshino T

更新日期：1992-01-01 00:00:00

abstract：:A case of secretory meningioma with numerous meningothelial rosettes is reported. A 66-year-old man with moyamoya disease gradually developed skull deformity, and underwent surgery for the skull tumor overlying the hemisphere. Histological examination disclosed numerous meningothelial rosettes quite similar to those i...

journal_title：Acta neuropathologica

authors： Tada T,Ishii K,Oshima S,Hara H,Kobayashi S

更新日期：1992-01-01 00:00:00

abstract：:Pathways for drainage of interstitial fluid and cerebrospinal fluid from the rat brain were investigated by the injection of 2-5 microliters Indian ink into cerebral white and grey matter and into the subarachnoid space over the vertex of the left frontal lobe. Animals were killed by formalin or glutaraldehyde perfusi...

journal_title：Acta neuropathologica

authors： Zhang ET,Richards HK,Kida S,Weller RO

更新日期：1992-01-01 00:00:00

abstract：:The left and right recurrent laryngeal nerves and peroneal nerves from two groups of foals, one less than 1 month of age and the other 6 months of age, were examined by light and electron microscopy. While there was no evidence of fiber loss on light microscopy, occasional onion bulbs, regenerating clusters and swolle...

journal_title：Acta neuropathologica

authors： Duncan ID

更新日期：1992-01-01 00:00:00

abstract：:Gliomas induced in the rat by transplacental administration of ethylnitrosourea (ENU) are intensely immunoreactive for vimentin and scarcely for glial fibrillary acidic protein (GFAP). Since tumoral transformation takes place during the late fetal and early postnatal period, the sequential expression of the two glial ...

journal_title：Acta neuropathologica

authors： Giordana MT,Migheli A,Mocellini C,Villare F,Schiffer D

更新日期：1992-01-01 00:00:00

abstract：:We studied a case of primary leptomeningeal glioma (PLG) on the left parietal lobe of a 74-year-old woman and compared the tissue with heterotopic glial tissue from another case. The PLG tumor consisted of spindle-shaped cells with marked nuclear atypism, which tended to be arranged in a fascicular pattern, and the ma...

journal_title：Acta neuropathologica

authors： Kakita A,Wakabayashi K,Takahashi H,Ohama E,Ikuta F,Tokiguchi S

更新日期：1992-01-01 00:00:00

abstract：:Underlying the Lambert-Eaton myasthenic syndrome (LEMS) is a decrease in the release of the neurotransmitter acetylcholine. Only few reports on light and transmission electron microscopical observations of motor endplates in LEMS are available and changes reported so far differ from those found in experimental blockin...

journal_title：Acta neuropathologica

authors： Hesselmans LF,Jennekens FG,Kartman J,Wokke JH,de Visser M,Klaver-Krol EG,DeBaets M,Spaans F,Veldman H

更新日期：1992-01-01 00:00:00

abstract：:Histological, ultrastructural and morphometrical observations on Clarke's column were carried out in 18 patients with sporadic amyotrophic lateral sclerosis (ALS) and 15 age-matched control subjects. Of the 18 ALS patients 6 had been on a respirator before death. Bunina bodies were found in the neuronal cytoplasm in 7...

journal_title：Acta neuropathologica

authors： Takahashi H,Oyanagi K,Ohama E,Ikuta F

更新日期：1992-01-01 00:00:00

abstract：:A Schwann cell can form only one internode of myelin around an axon. However, we observed the formation by a single Schwann cell of myelin around two axons of different diameters in the sural nerve of a 45-year-old man with mononeuritis multiplex. Schwann cell processes spiraled in the same direction around each axon,...

journal_title：Acta neuropathologica

authors： Kusaka H,Imai T,Matsumoto S,Ito H,Yamasaki M

更新日期：1992-01-01 00:00:00

abstract：:We have found large eosinophilic bodies in the pericapillary regions of the gray and white matter in the human spinal cord. These are entirely different from the previously reported pericapillary inclusion bodies (PIB). We have designated them pericapillary rosettes (PR), since they consist of clusters of round or ovo...

journal_title：Acta neuropathologica

authors： Sasaki S,Maruyama S

更新日期：1992-01-01 00:00:00

abstract：:Histological, immunohistochemical and ultrastructural sural nerve and skin biopsy findings in a case of cryoglobulinemia secondary to an IgM-kappa-producing non-Hodgkin lymphoma are described. The main finding was an occlusive microangiopathy present in both the sural nerve and the skin. Widespread cryoglobulin deposi...

journal_title：Acta neuropathologica

authors： Prior R,Schober R,Scharffetter K,Wechsler W

更新日期：1992-01-01 00:00:00

abstract：:This report deals with the expression of stress-response (heat-shock) protein 72 (srp 72) in a series of 95 primary human brain tumors and 21 carcinoma metastases to the central nervous system (CNS). Immunohistochemical procedures were employed; cells of the human cervical cancer line HeLa S3 were used as positive con...

journal_title：Acta neuropathologica

authors： Kato S,Hirano A,Kato M,Herz F,Ohama E

更新日期：1992-01-01 00:00:00

abstract：:Unusual inclusions with some of the features of "reducing bodies" were encountered in the skeletal muscle biopsy of a 2.5-year-old boy with childhood-onset acid maltase deficiency. The biopsy revealed a vacuolar myopathy with lysosomal storage of glycogen and eosinophilic refractile inclusions in myofibers, which appe...

journal_title：Acta neuropathologica

authors： Jay V,Christodoulou J,Mercer-Connolly A,McInnes RR

更新日期：1992-01-01 00:00:00

abstract：:The occurrence and topographic analysis of granulovacuolar degeneration (GVD) in the hippocampal cortex of mentally normal controls (75 cases) and patients with Alzheimer's dementia (AD; 17 cases which included Alzheimer's disease and senile dementia of Alzheimer type), multi-infarct dementia (MID; 16 cases), Pick's d...

journal_title：Acta neuropathologica

authors： Xu M,Shibayama H,Kobayashi H,Yamada K,Ishihara R,Zhao P,Takeuchi T,Yoshida K,Inagaki T,Nokura K

更新日期：1992-01-01 00:00:00

abstract：:Human recombinant tumor necrosis factor-alpha (rTNF-alpha) was administered to normal Fischer 344 rats by stereotaxic intracerebral (IC) injection. Animals received a single injection of either 6 x 10(4) U rTNF-alpha or excipient in their right parietal lobe. Others received three consecutive daily injections of eithe...

journal_title：Acta neuropathologica

authors： Wright JL,Merchant RE

更新日期：1992-01-01 00:00:00

abstract：:A unique pathological finding of astrocytes was observed in the brain of a 20-year-old man who had severe physical and mental retardation. The brain was malformed showing micropolygyria in several cortical areas. A large number of hypertrophic astrocytes with eosinophilic granular substances in their cytoplasm were fo...

journal_title：Acta neuropathologica

authors： Minagawa M,Shioda K,Shimizu Y,Isshiki T

更新日期：1992-01-01 00:00:00

abstract：:A limited cortical resection including the rolandic fissure and the pre- and postcentral cortical regions was carried out in a patient suffering from epilepsia partialis continua resistant to antiepileptic drugs. The histological examination revealed several foci of very large neurons distributed with no laminar organ...

journal_title：Acta neuropathologica

authors： Ferrer I,Pineda M,Tallada M,Oliver B,Russi A,Oller L,Noboa R,Zújar MJ,Alcántara S

更新日期：1992-01-01 00:00:00

abstract：:Spinal cord of the rat was investigated immunohistochemically to detect signs of extravasation of fibronectin in animals in which the cord was subjected to different degrees of compression trauma. Immunohistochemistry was performed after survival periods of 4 and 24 h and parallel sections were incubated for albumin i...

journal_title：Acta neuropathologica

authors： Farooque M,Zhang Y,Holtz A,Olsson Y

更新日期：1992-01-01 00:00:00

abstract：:The presence and distribution of human immunodeficiency virus (HIV) were examined in the CNS of two children with severe HIV encephalitis and myelitis. Using polymerase chain reaction-mediated DNA amplification and subsequent Southern analysis, proviral HIV gag sequences were identified in brain tissue of both patient...

journal_title：Acta neuropathologica

authors： Brüstle O,Spiegel H,Leib SL,Finn T,Stein H,Kleihues P,Wiestler OD

更新日期：1992-01-01 00:00:00

abstract：:Aim of the present study was to establish different immunohistochemical staining patterns for a subsequent comparison with those of primitive neuroectodermal (PNET) subsets, i.e. PNET-NOS (not otherwise specified) or PNET with focal neuronal, astrocytic or ependymal differentiation, to relate neoplastic to embryonal d...

journal_title：Acta neuropathologica

authors： Kleinert R

更新日期：1991-01-01 00:00:00

abstract：:We report a 69-year-old female with cerebral and cerebellar symptomatology of 15-month duration. At autopsy, both panencephalopathic Creutzfeldt-Jakob and plaque-predominant Alzheimer diseases were found. Plaque amyloid was exclusively of the beta/A4 type, but abundant abnormal protease-resistant protein was identifie...

journal_title：Acta neuropathologica

authors： Powers JM,Liu Y,Hair LS,Kascsack RJ,Lewis LD,Levy LA

更新日期：1991-01-01 00:00:00

abstract：:Three female cats, littermates born from clinically normal parents, were examined at 8 to 10 weeks of age because of a slowly progressive posterior ataxia. Another cat from a previous litter from the same parents suffered from similar neurological symptoms. Histopathological examination of the nervous tissues of these...

journal_title：Acta neuropathologica

authors： Moreau PM,Vallat JM,Hugon J,Leboutet MJ,Vandevelde M

更新日期：1991-01-01 00:00:00

abstract：:A 25-year-old homosexual AIDS patient presented with progressive cognitive, motor and behavioral disturbances consistent with HIV encephalopathy. CT scans demonstrated progressive diffuse brain atrophy. Neuropathology showed predominant cortical changes including severe neuronal loss corroborated by morphometry. Only ...

journal_title：Acta neuropathologica

authors： Gray F,Haug H,Chimelli L,Geny C,Gaston A,Scaravilli F,Budka H

更新日期：1991-01-01 00:00:00

abstract：:Fifteen cases of mitochondrial myopathy, three cases of hereditary motor and sensory neuropathy (HMSN) VI, and 280 cases of neuropathies of different etiologies were examined by electron microscopy for the presence of mitochondrial abnormalities in the sural nerve. Altered mitochondrial were found in most cases of mit...

journal_title：Acta neuropathologica

authors： Schröder JM,Sommer C

更新日期：1991-01-01 00:00:00

abstract：:The expression of glial fibrillary acidic protein (GFAP), vimentin, S-100 protein (S-100), HNK-1, myelin basic protein (MBP) and fibronectin was investigated immunohistochemically in 51 ethylnitrosourea (ENU)-induced neurinomas of the rat. Additionally, 90 transplantation tumors derived from ENU-induced neurinomas and...

journal_title：Acta neuropathologica

authors： Vogeley KT,Bilzer T,Reifenberger G,Wechsler W

更新日期：1991-01-01 00:00:00

abstract：:Experimental allergic neuritis was induced in Lewis rats by inoculation with autoreactive T cell lines sensitized to residue 57-81 of P2 myelin protein. Control rats received cells derived from immunization to complete Freund's adjuvant alone. Endoneurial fluid pressure (EFP) was measured in both sciatic nerves at 0, ...

journal_title：Acta neuropathologica

authors： Powell HC,Myers RR,Mizisin AP,Olee T,Brostoff SW

更新日期：1991-01-01 00:00:00

abstract：:Chronic wasting disease (CWD), a progressive neurological disorder of captive mule deer, black-tailed deer, hybrids of mule deer and white-tailed deer and Rocky Mountain elk, is characterized neuropathologically by widespread spongiform change of the neuropil, intracytoplasmic vacuolation in neuronal perikarya and ast...

journal_title：Acta neuropathologica

authors： Guiroy DC,Williams ES,Yanagihara R,Gajdusek DC

更新日期：1991-01-01 00:00:00

abstract：:The effect of induced hypertension instituted after a 2-h delay following middle cerebral artery occlusion (MCAO) on brain edema formation and histochemical injury was studied. Under isoflurane anesthesia, the MCA of 14 spontaneously hypertensive rats was occluded. In the control group (n = 7), the mean arterial press...

journal_title：Acta neuropathologica

authors： Patel PM,Drummond JC,Cole DJ,Giamela R,Steinauer J

更新日期：1991-01-01 00:00:00

abstract：:Both protein kinases and phosphoprotein phosphatases are important components of signal transduction systems in cells. Recent studies in Alzheimer's disease (AD) have shown abnormal protein phosphorylation in the cortex suggesting an alteration in these enzymes. In the present study, an antibody against CD45 was used ...

journal_title：Acta neuropathologica

authors： Masliah E,Mallory M,Hansen L,Alford M,Albright T,Terry R,Shapiro P,Sundsmo M,Saitoh T

更新日期：1991-01-01 00:00:00

abstract：:Mouse embryos were infected with murine cytomegalovirus (MCMV) by injecting the virus into the cerebral ventricles at the late gestation. After deliveries, offspring were fed by the mothers until 4 weeks. Cystic brain lesions, regarded as porencephaly or paraventricular cysts, were observed in about 20% of the MCMV-in...

journal_title：Acta neuropathologica

authors： Tsutsui Y,Kashiwai A,Kawamura N,Kadota C,Nagahama M

更新日期：1991-01-01 00:00:00

abstract：:The immunohistochemical distribution of alpha and beta subunits of S-100 protein (S-100 alpha, S-100 beta, respectively) in 138 cases of human brain tumors was investigated by the avidin-biotin immunoperoxidase method. Brain tumors can be divided into four groups: group 1 [S-100 alpha (+) and/or S-100 beta (+)]; astro...

journal_title：Acta neuropathologica

authors： Hayashi K,Hoshida Y,Horie Y,Takahashi K,Taguchi K,Sonobe H,Ohtsuki Y,Akagi T

更新日期：1991-01-01 00:00:00

abstract：:This study was designed to compare the degree of reactive astrogliosis occurring around a puncture wound in the brain of normal rats and at different intervals after a similar puncture wound in rats with a portocaval anastomosis. The gliosis was evaluated by the number of astrocytes, the thickness of their processes a...

journal_title：Acta neuropathologica

authors： Ma KC,Chang ZH,Shih H,Zhu JH,Wu JY

更新日期：1991-01-01 00:00:00

abstract：:Methylmercury (MeHg) poisoning (20 mg/kg body weight) in embryonic mice resulted in significant reductions of mitotic indices in the neuroepithelial germinal cells of the telencephalon at the ventricular surface 4 to 12 h following intoxication. After 24 h, no significant difference in the mitotic indices was observed...

journal_title：Acta neuropathologica

authors： Choi BH

更新日期：1991-01-01 00:00:00

abstract：:In chronic granulomatous disease (CGD) enzyme-deficient neutrophils and mononuclear cells lack the respiratory burst required for biocidal activity. Recurrent infections lead to granulomas in various organs but brain lesions are rare. In the present case, a 23-year-old male with numerous infections since early childho...

journal_title：Acta neuropathologica

authors： Hadfield MG,Ghatak NR,Laine FJ,Myer EC,Massie FS,Kramer WM

更新日期：1991-01-01 00:00:00

abstract：:A histopathological study was carried out on the brains of eight ex-boxers (ages 56 to 83) using conventional histological staining methods and immunocytochemistry with antibodies to amyloid beta-protein and the PHF-related tau protein. All cases showed a large number of tau-immunoreactive neurofibrillary tangles and ...

journal_title：Acta neuropathologica

authors： Tokuda T,Ikeda S,Yanagisawa N,Ihara Y,Glenner GG

更新日期：1991-01-01 00:00:00

abstract：:Seven patients aged 29 to 76 years with various clinical subtypes of chronic inflammatory demyelinating polyneuropathy (CIDP) were investigated. Sural nerve biopsies were performed between 7 months and 19 years after onset of disease. Quantitative electron microscopy revealed involvement of primary unmyelinated fibers...

journal_title：Acta neuropathologica

authors： Gibbels E,Kentenich M

更新日期：1990-01-01 00:00:00

abstract：:Bundles of paired helical filaments (PHF) accumulate in the pyramidal neurons that degenerate during Alzheimer's disease. This neurofibrillary degeneration is highly correlated with clinical signs of dementia. During the degenerating process, Tau proteins, which are the major antigenic components of PHF, are abnormall...

journal_title：Acta neuropathologica

authors： Delacourte A,Flament S,Dibe EM,Hublau P,Sablonnière B,Hémon B,Shérrer V,Défossez A

更新日期：1990-01-01 00:00:00

abstract：:The long-term survival of oligodendrocytes in the absence of axons in adult animals was studied following Wallerian degeneration of the optic nerves of adult rats for periods up to 22 months. In contrast to the findings in development and in young animals, large numbers of oligodendrocytes survived during this time pe...

journal_title：Acta neuropathologica

authors： Ludwin SK

更新日期：1990-01-01 00:00:00

abstract：:The ontogenesis of Fc gamma receptors (FcR) and C3b/C4b receptors (CR1) was studied in peripheral nerves from ten fetuses aged from 20 to 38 weeks using immunohistochemical and functional assays. Monoclonal antibodies (mAbs) against FcR and CR1 stained nerve fibers at 10 weeks of gestation and the staining intensity i...

journal_title：Acta neuropathologica

authors： Vedeler CA,Scarpini E,Beretta S,Doronzo R,Matre R

更新日期：1990-01-01 00:00:00